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Grams: NUTRITION
 

 
Name: Dr. Vijayalakshmi Venkatesan, M.Sc.Biochemistry,Ph.D.
Scientist ‘F’ & HoD, Stem Cell Biology
Contact:  
Phone: +91-40-27197301
E-mail: v.venkateshan@ninindia.org; v.venkateshan@gmail.com
 

Brief Profile:

She carried out her post doctoral research at the Centre for Cellular and Molecular Biology (CCMB), Hyderabad and worked in the research area of Cell biology towards “Understanding the Cellular and Molecular Regulation of the Genomic and Non-genomic responses of Estradiol and modulation of the Transglutaminase activity in the Vaginal epithelial Cells”

Subsequently, joined as Faculty, Scientist ‘D’ (DBT-Supported) at Centre for Liver Research, Owaisi Hospital & Research Centre, Hyderabad and worked in the area of Hepatobiology and cellular therapy in the management of acute liver failure.

Joined NIN in 2002, and currently heading the stem cell facility at NIN. The primary focus has been to harness the potential(s) of stem cells isolated from the adult tissue /progenitors and we are trying to understand the nutrient interactions in the microenvironment of the stem cells and their programming towards the insulin secreting cells. This is essentially from the primary cultures islets, intra islet precursors and mesenchymal cells. This also involves the Tissue culture work and using the state-of-th-art techniques such as Confocal microscopy, FAX and PCR the cellular and molecular characterization is being undertaken.

Her Division is also developing the cell lines from the adipose, pancreatic and Kidney tissues of the NIN mutant Obese rats funded by DBTwith NIN-NCCS as an alternate to the in vivo system.

The efficacy of Human Umbilical Cord Serum(HUCS) as an alternative to FCS is also being investigated in primary cultures,stem cells and cell lines.(Publications enclosed)

 

List of Publications:

1. S. Thanumalayan, V. Venkatesan, M. Laxmi Narasu. (2008) ‘Sub-cellular localization of suppressor of potassium transport defect 3 (SKD3) into nucleus and nuclear matrix. Indian Journal of Science and Technology Vol.1 No 3. ’

2. S.Thanumalayan,M Laxmi Narsu,V.Venkatesan (2008)Down regulation of suppressor of potassium transport defect 3 (SKD3) in testis of nonobese diabetic (NOD) mice.Ind J Vet Pathol.,32(2):242-245,

3. Raj K Dorisetty, Sashi G Kiran, Malathi R Umrani, Sesikeran Boindala, Ramesh R Bhonde, Vijayalakshmi Venkatesan, (2008) Immunolocalization of nestin in pancreatic tissue of mice at different ages. World J Gastroenterol December 14; 14(46): 7112-7116.

4. Vijayalakshmi.V, Sashi Kiran.G.( 2008) Pluripotency of spermatogonial stem cells from adult mouse testis.’ Conference on Recent Advances and Challenges in Reproductive Health Research. Editors: RS Sharma, A Rajanna , M Rajalakshmi

5. Y.R. Ahuja , V. Vijayalakshmi , and K. Polasa. (2007) Stem cell test: a practical tool in toxicogenomics. Toxicology 231 1–10.

6. Smruti M. Phadnis, Mugdha V. JoglekarVijayalakshmi Venkateshan, Surendra M. Ghaskadbi, Anandwardhan A. Hardikar, Ramesh R. Bhonde ,( 2006)Human Umbilical Cord Blood Serum Promotes Growth, Proliferation as well as Differentiation of Human Bone Marrow-derived Progenitor Cells. In vitro Cellular and Developmental Biology- Animal, 42: 283-286,

7. Vijayalakshmi V, Maniprabha C, Sesikeran B and Bhonde RR. (2005) Identification and Characterization of Pancreatic Progenitors From Adult Pancreatic Tissue. Ranbaxy Science Foundation; Stem cell Research: From Bench to Bedside. Pg 29-33 Ed: OP Sood, RS Bakshi; Eleventh Annual symposium,

8. Naseem Begum Shakeel, Vijayalakshmi V, Parveen, Adarsh K Capoor, , Mohammed Aejaz Habeeb, Ansar Ali Khan, Syed Muzeeb, NVS Rao Mamidi, Aleem Ahmed Khan, Chittoor Mohammed Habibullah (2005) Effect of ultraviolet B (302nm) irradiation on viability, metabolic and detoxificationfunctions of goat hepatocytes-In vitro study. Molecular and Cellular Biochemistry 277, 49-53.

9. V.Vijayalakshmi V, B.Naseem , AA Khan , AK Capoor and CM Habibullah (2004).Comparison of biochemical and cytotoxic functions of hepatocytes from goat, pig and human fetuses. Journal of Gastroenterology and Hepatology. 19; 1029-1035.

10. Vijayalakshmi V, Naseem B.S, Nalam Madhusudhan Rao, Vijayalakshmi Amash, Rangarajan Nandini, Mohammed Habibullah Chittoor.(2004). Differential Responses of UV-B irradiation on the viability and intracellular calcium influx in goat hepatocytes – in vitro effect. Molecular and Cellular Biochemistry, 266:161-166.

11. Goats to de-liver cells for transplants in India (2003). Nature Medicine: 9, (5), May 491. (citation of the article).

12. Naseem B,Vijayalakshmi V, Khan AA, Capoor AK and Habibullah CM. (2003).Zoonotic screening of Goat liver/ blood- Implications in Xenotransplantation. Indian vet.Journal . 80; 1010-1014).

13. Aleem A Khan, Adarsh K Capoor, Parveen N, Shakeel Naseem, Vijayalakshmi Venkateshan V, Chittoor M Habibullah. ( 2002) In vitro studies on a bioreactor module containing encapsulated goat hepatocytes for the development of bioartificial liver. Indian J Gastroenterol. 21:55-58 Pg 11-16,

14. Vijayalakshmi V,Naseem B and Habibullah CM (2000) In Vitro Comparison of Antibody Mediated Cell Lysis of Human Fetal, Adult Porcine and Goat Hepatocytes. Hepatology 32,1811-1812

15. C. M Habibullah, V Vijayalakshmi, B Naseem ,M H Habeeb,S Shashi, M N Rao (2000).Hepatofunctional study of UV-B (302 nm) irradiated goat hepatocytes. American Journal Of Gastroenterology Vol. no.95, 2511-2512

16. S.Shashi, A.G. Reddy, K.S. Rao,V. Vijayalakshmi R.Kumaresh and P.D. Gupta. (1998).Organization of keratin filaments following phosphorylation by Estradiol in Rat Vaginal Epithelial Cells. Electron Microscopy in biology(Edited by Dr P.D.Gupta Dr Yamamoto,IBH publishers,Oxford) page : 18-27.

17. V.Vijayalakshmi.and P.D. Gupta. (1997).Role of calcium dependent transglutaminase in keratinization of vaginal epithelial cells in cycling rats . Biochem. Mol. Biol. Int. 43/5 1041-1049

18. P.D. Gupta and V. Vijayalakshmi. (1996). Association of transglutaminase like antigen with cytoskeletal proteins. Current Science. 71 (9): 665-666

19. K. Chandrashekhar, V. Vijayalakshmi and Y.G. Deosthale. (1995). Fatty acid profiles of some Indian species . J. Fd. Sci. Technol. 32 (5) 403-405

20. V.Vijayalakshmi and P.D. Gupta. Estradiol regulated transamidation of keratins by vaginal epithelial cell transglutaminase. Exper. Cell Res. 241: 358-366. (1994)

21. V. Vijayalakshmi and P.D. Gupta. (1994).Association of transglutaminase with the reconstituted keratin filaments of the rat vaginal epithelial cells . Epithe. Cell Biol. 3(4): 168-174

22. P. Suresh, V.K. Inglay and V. Vijayalakshmi. (1992). Anti-bacterial activity of Eugenol in comparison with other transglutaminase . J. Fd. Sci. Technol. 29: 254-256

23. R. Vijayalakshmi, S.S.Y.H. Quadri and Y.G. Doesthale. (1991). Effect of acute and chronic dose of Eugenol on the gastric function in rats. J.Clin. Biochem. & Nutr. 10: 161-169

24. Leela Raman, R.Vijayalakshmi and Yeshodara. (1989). Factors influencing glucose, insulin and free fatty acid resonse to glucose load in Indian pregnant women J.Clin. Biochem. & Nutr. 6: 159-165.

25. R.Vijayalakshmi, M.S. Bamji and B.A. Ramalakshmi. (1988).Reduced anaerobic glycolysis in women taking the combination type of oral contraceptives. Contraception, 38 (1):91-97

26. R.Vijayalakshmi and M.S. Bamji. (1987).Alteration of glucose metabolism with Steroidal contraceptives-reversal by excess pyridoxine . Ind. J. Biochem. Biophys. 24: 329-335.


Patent filed:

In Vitro Characterisation and Therapeutics, Use of goat Hepatocytes in acute Liver Failure on model systems.Vijayalakshmi Venkatesan, Naseem B Aleem A K, Adarsh K Capoor, M Aejaz and Habibullah CM .( 1283/Del/02) dated 19.12.02 Indian patent.

• Method for isolating the progenitor liver cells from fetal liver cells and their transdifferentiation .. Aleem A K,Parveen, Adarsh K Capoor, Naseem B, Vijayalakshmi Venkateshan, M Aejaz and Habibullah CM (Patent Filing No. 395/MAS/2002)


B) Professional communication to Journals / Magazines:

• Goats to de-liver cells for transplants in India. Nature Medicine 9 (5), 491 May (2003).

• Goat Liver gives hope. Habibullah CM, Vijayalakshmi V, Naseem B, Aleem AA Khan, Aejaz MH and Adarsh KC. Nature- News India, June 2003.


C) Popular articles:

• Xenotransplantation: ,( 2002).An over view. V.Vijayalakshmi, CM Habibullah, Medical Bulletin, Owaisi Hospital, 103-105DBT finds goat liver cells ideal for human transplant, to fight for patent. V.Vijyalakshmi, CM Habibullah and Naseem, Express Pharma Pulse,

• Goat: A great source of cells for liver transplant. Habibullah CM, Vijayalakshmi V, Naseem B, Aleem AA Khan, Aejaz MH and Adarsh KC. (2002)

• The Goat Farmer, Goat useful for liver transplants. Habibullah CM, Vijayalakshmi V, Naseem B, Aleem AA Khan, Aejaz MH and Adarsh KC. Press trust of India, 2003.


D) News:

1. National Institute of Nutrition. Biotech News of DBT, India. Vol II (4), 9-10, Aug 2007


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