National Institute of Nutrition
Jamai-Osmania PO
Hyderabad-500 007, India.
Ph No: #+914027197200
Email: ,
FAX: 04027019074

Name: Dr.S.M.Jeyakumar, M.Sc., M.Phil., Ph.D.
Designation : Scientist  ‘D'
Phone: +91-040-2719 7341
E-mail: &

Brief Profile:

Graduated in Chemistry from Madurai Kamaraj University. Postgraduate and Master of Philosophy degrees from Annamalai University in Biochemistry. Joined 1999, at National Institute of Nutrition (ICMR) for doctoral studies under the guidance of Dr.A.Vajreswari and received Doctor of Philosophy in Biochemistry from Osmania University, Hyderabad in 2005 and  worked as Post-Doctoral Fellow for a year.  February 2006, joined the institute as Scientist ‘B’, subsequently promoted to scientist “C” and currently holding the position of Scientist “D” and continuing my research in the area of disease biology, molecular nutrition, and fats & oils in human health.
Our research group is comprised of Ph.D. scholars, Project JRFs, Technical officer and supporting staffs.  Our primary research focus is to understand the role of vitamin A, dietary fats in obesity and its associated complications; particularly insulin resistance and non-alcoholic fatty liver disease (NAFLD) and the role of sex hormones using different experimental models. In addition, our current research focuses on identifying nutraceuticals from vegetables and fruits, possessing anti-adipogenic and insulin-sensitizing properties.
Our research programs are being supported by ICMR and DBT. We use diet-induced, genetic rodent models and mammalian cell line models and our study involves various analytical techniques; including HPLC, GLC and RT-PCR.



Total publications: 23
Publications in the last 10 years
  1. Jeyakumar SM, Sheril A, Vajreswari A. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain. Indian J Med Res. 2016 Aug;144(2):238-244.
  2. Mahesh M, Bharathi M, Reddy MR, Kumar MS, Putcha UK, Vajreswari A, Jeyakumar SM. Carrot Juice Administration Decreases Liver Stearoyl-CoA Desaturase 1 and Improves Docosahexaenoic Acid Levels, but Not Steatosis in High Fructose Diet-Fed Weanling Wistar Rats. Prev Nutr Food Sci. 2016 Sep;21(3):171-180.
  3. Mahesh M, Bharathi M, Raja Gopal Reddy M, Pappu P, Putcha UK, Vajreswari A, Jeyakumar SM. Carrot juice ingestion attenuates high fructose-induced circulatory pro-inflammatory mediators in weanling Wistar rats. J Sci Food Agric. 2017 Mar;97(5):1582-1591.
  4. Raja Gopal Reddy M, Pavan Kumar C, Mahesh M, Sravan Kumar M, Jeyakumar SM. Expression data on liver metabolic pathway genes and proteins. Data Brief. 2016 Jan 13;6:625-9.
  5. Asha GV, Raja Gopal Reddy M, Mahesh M, Vajreswari A, Jeyakumar SM. Male mice are susceptible to high fat diet-induced hyperglycaemia and display increased circulatory retinol binding protein 4 (RBP4) levels and its expression in visceral adipose depots. Arch Physiol Biochem. 2016;122(1):19-26.
  6. Raja Gopal Reddy M, Pavan Kumar C, Mahesh M, Sravan Kumar M, Mullapudi Venkata S, Putcha UK, Vajreswari A, Jeyakumar SM. Vitamin A deficiency suppresses high fructose-induced triglyceride synthesis and elevates resolvin D1 levels. Biochim Biophys Acta. 2016 Mar;1861(3):156-65
  7. Jeyakumar SM, Vajreswari A. Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model. Indian J Med Res. 2015 Mar;141(3):275-84
  8. Jeyakumar SM, Sheril A, Vajreswari A. Chronic vitamin A-enriched diet feeding induces body weight gain and adiposity in lean and glucose-intolerant obese rats of WNIN/GR-Ob strain. Exp Physiol. 2015 Nov;100(11):1352-61.
  9. Prashanth A, Jeyakumar SM, Singotamu L, Harishankar N, Giridharan NV, Vajreswari A. Mitochondriogenesis and apoptosis: possible cause of vitamin A-mediated adipose loss in WNIN/Ob-obese rats. Nutr Metab (Lond). 2014 Sep 25;11(1):45
  10. Prashanth A, Jeyakumar SM, Giridharan NV, Vajreswari A. Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain. J Atheroscler Thromb. 2014;21(11):1197-207
  11. Jeyakumar SM, Prashant A, Rani KS, Laxmi R, Vani A, Kumar PU, Vajreswari A. Chronic consumption of trans-fat-rich diet increases hepatic cholesterol levels and impairs muscle insulin sensitivity without leading to hepatic steatosis and hypertriglyceridemia in female Fischer rats. Ann Nutr Metab. 2011 Oct;58(4):272-80
  12. Yasmeen R, Jeyakumar SM, Reichert B, Yang F, Ziouzenkova O. The contribution of vitamin A to autocrine regulation of fat depots. Biochim Biophys Acta. 2012 Jan;1821(1):190-7.
  13. Jeyakumar SM, Vijaya Kumar P, Giridharan NV, Vajreswari A. Vitamin A improves insulin sensitivity by increasing insulin receptor phosphorylation through protein tyrosine phosphatase 1B regulation at early age in obese rats of WNIN/Ob strain. Diabetes Obes Metab. 2011 Oct;13(10):955-8
  14. Reichert B, Yasmeen R, Jeyakumar SM, Yang F, Thomou T, Alder H, Duester G, Maiseyeu A, Mihai G, Harrison EH, Rajagopalan S, Kirkland JL, Ziouzenkova O. Concerted action of aldehyde dehydrogenases influences depot-specific fat formation. Mol Endocrinol. 2011 May;25(5):799-809
  15. Jeyakumar SM, Lopamudra P, Padmini S, Balakrishna N, Giridharan NV, Vajreswari A. Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob. Nutr Metab (Lond). 2009 Jun 11;6:27
  16. Sheril A, Jeyakumar SM, Jayashree T, Giridharan NV, Vajreswari A.Impact of feeding polyunsaturated fatty acids on cholesterol metabolism of dyslipidemic obese rats of WNIN/GR-Ob strain. Atherosclerosis. 2009 May;204(1):136-40
  17. Jeyakumar SM, Vajreswari A, Giridharan NV.Vitamin A regulates obesity in WNIN/Ob obese rat; independent of stearoyl-CoA desaturase-1. Biochem Biophys Res Commun. 2008 May 30;370(2):243-7
  18. Jeyakumar SM, Vajreswari A, Giridharan NV. Impact of vitamin A on high-density lipoprotein-cholesterol and scavenger receptor class BI in the obese rat. Obesity (Silver Spring). 2007 Feb;15(2):322-9.

Total number of books and book chapters: 1

Carotenoids and Vitamin A in Translational Medicine.  In: Sommerburg O, Siems W and Kraemer K, editors “Metabolism of vitamin A in white adipose tissue and obesity” CRC Press; 2013. p. 23-51 & ISBN No.9781439855263

Award and recognition
International Fellow of Young Biomedical Scientist for the year 2009 by Indian Council of Medical Research Ramanathan Award for the year 2015 by Nutrition Society of India.
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