National Institute of Nutrition
Jamai-Osmania PO
Hyderabad-500 007, India.
Ph No: #+914027197200
Email: ,
FAX: 04027019074

Designation : SCIENTIST ‘E’
Phone: +91-40-27197202

Brief Profile:

Joined ICMR in August 1980, and spent 13 years in Food & Drug Toxicology Division of the Institute, wherein he worked on chemical, nutritional and toxicological evaluation of unconventional oils. He went on to do his MSc in applied zoology from the Central University of Pondicherry, he moved to National Centre for Laboratory Animal Sciences (NCLAS) in 1993 to pursue Ph.D in Zoology, which was awarded to him in 2002 from Osmania University. His doctoral work was on the establishment and characterization of the obese mutant rats established at the centre. He is currently associated with the National Centre for Laboratory Animal Sciences (NCLAS) and is involved in all the centres activities like breeding and supply of animals as well as in training of personnel in handling lab animals both regular and adhoc. He was instrumental in establishing the “State-of the – Art” small animal physiology laboratory in the centre. He underwent training programme on high end instruments like IVIS-201 and 7T MRI at USA and successfully imparted the technique at the centre. His areas of interest include development of alternative animal models for oncogenic studies, animal physiology, animal behaviour, and also pre-clinical toxicology.


Total publications: 40
Publications in the last 10 years
  1. Owais MB, Uday KP, Harishankar N, Ravichandaran L, Bhatia A, Veena D. Interleukin-18-induced cell adhesion molecule expression is subjected to feedback regulation by PPAR-γ and NF-κB in Apo E-/- mice. Molecular and Cellular Biochemistry. doi.10.1007/s11010-016.2922.8.
  2. Karnam S, Reddy SS, Reddy PY, Sivalingam P, Harishankar N, Reddy GB. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. The Journal of Nutritional Biochemistry. 2016; 30: 73-81
  3. Shivaram N, Uday KP, Madhusudhanachary P, Sailaja P, Giridharan N, Harishankar N. Botulinum Neurotoxin effects on Masseter Muscle fibre in WNIN obese rats – Scanning Electron Microscope Analysis. Scanning. 2016; 38: 396-402
  4. Hemalatha R, Annapurna VV, Ramaraju AVS, NarendraBabu K, Thirupathaiah Y, ShujauddinMd, Harishankar N, Balakrishna N. Selective ceacal bacterial changes mediate the adverse effects associated with high palmolein or high starch diets: Prophylactic role of Flax oil. International Journal of Pharmacognosy and Phytochemical Research. 2015; 7 (11): 89-95.
  5. Dinesh T, Manish KJ, Shweta S, Harishankar N, Ravindar NR,  Pradip C, Naidu VGM Thymoquinone inhibits RANKL induced osteoclastogenesis by suppressing nf-kb and mapk signalling: a study in macrophage cells and mouse model of bone loss. Pharmacological Research. 2015: 99: 63-73
  6. Padmalatha C, Shivaram N, KiranKuma P, Naveen R, Sarita T, Harishankar N, Effect of CPP-ACP, polarized enamel using hydrogen peroxide on reminerlizing potential of bovine – an ex-vivo study. International Journal of Current Research. 2015; 7 (4): 15230-15233 
  7. Muzammil AS, Naidu VGM, Harishankar N, Kishan V. albumin anchored docetaxel lipid nanoemulsion for improved targeting efficiency-preparation, characterization, cytotoxic, antitumor and in vivo imaging studies. Drug Delivery. 2016: May;23(4):1355-63
  8. Parim BN, Harishankar N, Balaji M,Sailaja P, Sajjalaguddam R. Effects of Piper nigrum extract: Restorative perspectives of high fat diet induced changes on lipid profile, body composition and hormones in Sprague Dawley rats. Pharmaceutical Biology.  2015: 53 (9): 1318-1323.
  9. Nirupama L, Rajender KR, Pothani S, Shahidul I, Harishankar N, Giridharan NV, Bharati K, Vijayalakshmi V. Obesity and mitochondrial dysfunction-evidences from WNIN mutant rats. World Journal of Pharmaceutical Research.2015; 4(3): 1074-1096  IF:5.990.
  10. Satyavani M, Uday KP, Harishankar N, Ravindar NR, Suresh P “Sprague Dawley /NIN hairless mutant rat- A model to study Carcinogenesis?” – Journal of Cancer Science and Therapy. 2015; 7:8
  11. Prashanth A, Shanmugam MJ, Singotamu L, Harishankar N,  Giridharan NV, Vajreswari A. Mitochondriogenesis and apoptosis: possible cause of vitamin A-mediated adipose loss in WNIN/Ob-obese rats. Nutrition and Metabolism. Sep.2014. doi:10.1186/1743-7075-11-45.
  12. YucangL,Cule W, Dolly M, Ragamouni S, Harishankar N, Gopal P, Peter H. Collagen type-I leads to in vivo matrix mineralization and secondry stabilization of Mg-Zr-Ca alloy implants. Colloids Surf B Biointerfaces. 2014: 1;122:719-728
  13. Parim BN, Harishankar N, Balaji M, Santosh KM, Sailaja P, Sajjalaguddam R. Mitigating efficacy of piperine in the physiological derangments in high fat diet induced obesity in spraguedawley rats. Chemico Biological Interaction. 2014;  31:221C:42-51
  14. Mushahary D, Wen C, Kumar JM, Harishankar N, Pande G, Hodgson P, Li Y. Effect of Collagen type-I on the rate of osseointegration of Ca-containing biodegradable Mg-Zr based alloys. European Cells and Materials. 2013; 26 (6): 1473-2262
  15. Amit KJ, Rohit VD, Sandipto G, Pradip C, Harishankar N, Vivek PS, Geeta RV, Jayesh RB. Bone healing evaluation of nanofibrous composite scaffolds in rat calvarial defects: A comparative study. Journal of Biomedical  Nanotechnology. 2013: 9(12): 2073-2085
  16. Dolly M, Ragamouni S, Jerald M, Harishankar N, Gopal P. Zr, Ca and Sr Contents in Mg based biodegradable alloys modulate the efficiency of implant induced osseointegration. International Journal of Nanomedicine.2013; 8: 2887–2902.
  17. Sravanthi R, Jerald MK, Dolly M, Harishankar N, Gopal P. Histological analysis of cells and matrix mineralizationof new bone tissue induced in rabbit femur bones by Mg-Zr based biodegradable implants. ActaHistochemica. 2013; 115 (7):748-56.
  18. Anand KK, Lalitha A, Pavithra D, Padmavathi IJN, Manisha G, Rajender RK, Venu L, Balakrishna N, Harishankar N, Umakar RS, Giriraj RC, Shantanu S, Raghunath M. Maternal dietary folate and / or vitamin b12 restrictions alter body composition (adiposity) and lipid metabolism in wistar rat offspring. Journal of Nutritional Biochemistry.2013; 24: 25-31
  19. Harishankar N, Giridharan NV. Restoration of libido in WNIN/GR-Ob rats by administration of high dose of Testosterone propionate. Advanced studies in biology. 2012; 12: 557-571
  20. Prasad SSSV, Mahesh S, Vijay KP, Harishankar N, Uday KP, Shailaja P, Swarupa RK, Lakshmi RKP, Vani A, Giridharan NV, Vajreswari A. Carbenoxolone treatment ameliorated metabolic syndrome in WNIN/Ob obese rats, but induced severefat loss and glucose intolerance in lean rats. PLOS ONE.  2012; Vol 7; Issue 12; e50216.
  21. YucangL,Cule W, Dolly M, Ragamouni S, Harishankar N, Gopal P, Peter H. Mg-Zr-Sr alloys as biodegradable implant materials. ActaBiomaterialia. 2012; 8; 3177–3188
  22. Satishkumar M, Ali Y, Sailaja P, Mahesh S , Surekha MV, Giridharan NV, Harishankar N. Therapeutic properties of Mucunapruriens Linn – an Unani drug, in a prediabetic obese rat model.  International Journal Body composition Research. 2012; 10: 1-8
  23. Harishankar N, Seshadri E, Subramanyam K, Giridharan NV.Impaired glucose tolerance (IGT) to frank diabetes, by dietary manipulations in WNIN/GR-Ob rats.Journal of Diabetes Mellitus. 2012; 2(1): 52-58
  24. Harishankar N, Punjal R, Nair MK,  Giridharan NV. Infertility in WNIN obese mutant rats – causes ?. ISRN Endocrinology. 2011. doi:10.5402/2011/863403.
  25. Harishankar N, Vajreswari A, Giridharan NV.WNIN/GR-Ob – An insulin-resistant obese rat model from inbred WNIN strain. Indian Journal Medical Research. 2011; 134: 320-329
  26. Harishankar N, Uday KP, Sesikeran B, Giridharan NV. Obesity associated pathophysiological & histological changes in WNIN obese mutant rats. Indian Journal Medical Research. 2011; 134:330-340
  27. Manisha G, Sainath PB, Padmavathi IJN, Venu L, Kishore YD, Kalle A, Harishankar N, SrinivasaRao J,  Raghunath M. Maternal manganese restriction increases susceptibility to high fat diet induced dyslipidemia and altered adipose function in WNIN male rat offspring. Experimental Diabetis Research. 2011.
  28. Mir YA, Satish K, Rasheed NMA, Harishankar N. Effect of the seed of Linumusitatissimum activity on experimental rats. IJUR. 2011. 33-36.
  29. Satish K, Mir YA, Sailaja P, Mahesh S, Surekha MV,Giridharan NV, Harishankar N. The effect of Mucunapruriens seed extract on male reproductive hormones and spermatogenesis in WNIN/GR-Ob obese rats. International Journal Current Research. 2011; 3 (6): 323-327.
  30. Padmavathi IJN, RajenderRao K, Venu L, Narasimha R, Harishankar N, Ayesha I, Raghunath M. Chroinic Dietary restriction modulates visceral adiposity probable underlying mechanism. Diabetes. 2010; 59: 98-104
  31. Padmavathi IJN, Durga KY, Venu L, Manisha G, Harishankar N, Giridharan NV, and Raghunath M. Prenatal and Perinatal Zinc Restriction: Effects on body composition, glucose tolerance and insulin response in rat offspring. Experimental Physiology. 2009. 94(6), 761-769.
  32. Arjun LK, Uday KP, Harishankar N, Kalyanasundaram S. Effect of Fluoride intake (with and without Molybdenum and Copper) on Body composition; Organ weights and Histopathology – a study in rabbits.  Fluoride.2007. 40(3), 184-189.

Award and recognition
  1. Prof. Manjeeth Singh award for our work entitled “Carnosic acid Inhibits Osteoclastogenesis by Up Regulating the Nrf2 and Suppressing the NF-KB, MAPK Signaling” in Annual Conference of Indian Pharmacological Society, held at Guwahati from 28th to 29th December 2014.
  2. Prof. P.P.Suryakumari gold medal award for the best paper published on diabetes in 46th Annual Conference of Indian Pharmacological Society, held at Bangalore from 16th to 18th, December 2013.
  3. UK LTD bursary award to attend 7th Small Animal Imaging workshop held between 23rd to 27th of January 2012 at Tubingen University, Tubingen, Germany.
  4. Techniplast, Best poster award (sponsored trip to FELASA2010, at Helsinki, Finland) for our work entitled “WNIN/Ob, a Novel rat model to study oseoarthritis and osteoporosis” in the LASA conference held from 1st -3rd October 2009, NIRRH, at Mumbai.
  5. Dr.K.R.Bhardwaj, Best poster award for our work entitled “WNIN/Ob, a Novel rat model to study oseoarthritis and osteoporosis” in the LASA conference held between 1st -3rd October 2009, NIRRH, at Mumbai.
  6. ICN 2009 (International Congress of Nutrition) travel award for the paper entitled “Determination body composition in Syrian hamsters by non-invasive methods” presented during 19th International Congress of Nutrition, held between 4th –10th October 2009, BITEC, Bangkok, Thailand.
  7. CSIR best poster award In Experimental nutrition for the paper “Determination of body composition and activity in three commonly used rat strains” presented during the XXXVI Annual meetings of the Nutrition Society of India held between 5-6th , Nov.2004 at CFTRI, MYSORE.
  8. Young scientist award (Senior session) in Experimental nutrition for the paper presented during the XXXI Annual meetings of the Nutrition Society of India held on 26-28,Nov.1998 at National Institute of Nutrition, Hyderabad.

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