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Jamai-Osmania PO
Hyderabad-500 007, India.
Ph No: #+914027197200
Email: nin@ninindia.org ,
             nin@ap.nic.in
FAX: 04027019074
Grams: NUTRITION
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Name: G. Bhanuprakash Reddy, PhD, FNASc, FAPAS
Scientist ‘F’
Contact:  
Phone: +91-40-27197252
E-mail: geereddy@yahoo.com; bhanu@ninindia.org
Website: www.ninindia.org/Bhanu/default.asp
 

Brief Profile:

Dr. Reddy obtained his PhD in Biochemistry (1996) from Osmania University. He did postdoctoral trainings at the Indian Institute of Science, Bangalore and the Case Western Reserve University (USA). He joined the institute in 2000 and currently heads the Department of Ocular Biochemistry. He has been a Visiting Scientist in 2003, 2005 and 2007 at the University of Michigan and in 2014 at the Cincinnati Children’s Hospital and Medical Center.
He is a recipient of

  • ICMR-Basanti Devi Amir Chand Prize (2010)
  • Scopus India Young Scientist Award (2008)
  • RPB-International Research Scholars Award (2007)
  • ICMR-Excellent Research Output Award (2006)
  • ICMR-Dr. VN. Patwardhan Prize (2002), and
  • Nutrition Society of India (NSI) Young Scientist Award.

Dr. Reddy is a Fellow of

  • the National Academy of Sciences, India and
  • the AP Akademi of Sciences,

Dr. Reddy’s research is focused on nutrigenomics of age-related diseases, particularly complications of diabetes and obesity. His studies discovered a role for micronutrients in the development of diabetic complications. Importantly, he has revealed how deficiency of some micronutrients can influence the molecular processes and provided a basis for micronutrient involvement in diabetic complications using animal models. Also identified mutations in some genes that cause age-related diseases such as cataract and retinal degeneration. His studies are aimed at developing suitable animal models for studying the disease biology of diabetes, prediabetes and obesity associated complications and also to understand the role of nutrition. Dr. Reddy described age-related eye diseases- retinal degeneration and cataract in a spontaneous obese rat model. His pioneering work on involvement protein glycation and aldo-keto reductases under chronic hyperglycemia, paved the way for exploring functional foods molecules as aldose reductase inhibitors (ARI) and antiglycating agents (AGA). Further, isolated and characterized novel compounds from functional foods as ARI and AGA for combating diabetic complications. Dr. Reddy has provided new insights into the structure, function and expression of small heat shock proteins under hyperglycemic conditions and their modulation by nutritional factors. So far ten students have obtained PhD under his supervision. He has published over 110 research papers in peer-reviewed scientific journals and has two patents to his credit.

 

Selected publications (from a total of 110 publications)

1. VS Reddy and GB Reddy. Emerging role for αB-crystallin as a therapeutic agent: Pros and cons. Curr Mol Med 2015; 15:1-15

2. SS Jose, MS Radhika, N Balakrishna, GNV Brahmam, GB Reddy. Development of a raw food based quantitative food frequency questionnaire and evaluation of its validity and reproducibility among urban individuals of Hyderabad, India. International J Food Nutr Sci (IJFANS) 2014; 3(6): 1-8

3. Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact. 2014 Sep 6; 222C:68-76. PMID: 25199697

3. Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact. 2014 Sep 6; 222C:68-76. PMID: 25199697

5. Reddy SS, Shruthi K, Reddy VS, Raghu G, Suryanarayana P, Giridharan NV, Reddy GB. Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta. 2014 Sep; 1840(9):2924-34. PMID: 24949983

6. Akileshwari C, Raghu G, Muthenna P, Suryanaryana P, Mueller NH, Petrash JM, Reddy GB. Bioflavonoid ellagic acid inhibits aldose reductase: implications for prevention of diabetic complications. 2014; J Func Foods 6: 374-383.

7. Reddy VS, Raghu G, Reddy SS, Pasupulati AK, Suryanarayana P, Reddy GB. Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci. 2013 Nov 19; 54(12):7674-82 PMID: 24159092

8. Grama CN, Suryanarayana P, Patil MA, Raghu G, Balakrishna N, Kumar MN, Reddy GB. Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLoS One. 2013 Oct 14; 8(10):e78217. PMID: 24155984

9. Pasupulati AK, Reddy GB. Nutrition & metabolic syndrome. Rev Endocr Metab Disord. 2013 Sep; 14(3):217. PMID: 24052338

10. Kumar PA, Chitra PS, Reddy GB. Metabolic syndrome and associated chronic kidney diseases: nutritional interventions. Rev Endocr Metab Disord. 2013 Sep; 14(3):273-86.

11. Reddy PY, Giridharan NV, Balakrishna N, Validandi V, Pullakhandam R, Reddy GB. Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol. IUBMB Life. 2013 May; 65(5):472-8. PMID: 23504868

12. Balakumar M, Saravanan N, Prabhu D, Regin B, Reddy GB, Mohan V, Rema M, Balasubramanyam M. Benefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats. Indian J Exp Biol. 2013 Jan; 51(1):56-64.

13. Cukras C, Gaasterland T, Lee P, Gudiseva HV, Chavali VR, Pullakhandam R, Maranhao B, Edsall L, Soares S, Reddy GB, Sieving PA, Ayyagari R. Exome analysis identified a novel mutation in the RBP4 gene in a consanguineous pedigree with retinal dystrophy and developmental abnormalities. PLoS One. 2012; 7(11):e50205. PMID: 23189188

14. Pullakhandam R, Palika R, Ghosh S, Reddy GB. Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: the significance of transthyretin. IUBMB Life. 2012 Dec; 64(12): 975-82. PMID: 23129325

15. Tiruvalluru M, Ananthathmakula P, Ayyalasomayajula V, Nappanveettil G, Ayyagari R, Reddy GB. Vitamin A supplementation ameliorates obesity-associated retinal degeneration in WNIN/Ob rats. Nutrition. 2013 Jan; 29(1): 298-304. PMID: 23036575

16. Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012; 7(4):e31399. PMID: 22485126

17. Reddy PY, Giridharan NV, Reddy GB. Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats. Mol Vis. 2012; 18:495-503. Epub 2012 Feb 24. PMID: 22393276

18. Satyanarayana A, Balakrishna N, Pitla S, Reddy PY, Mudili S, Lopamudra P, Suryanarayana P, Viswanath K, Ayyagari R, Reddy GB. Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia. PLoS One. 2011; 6(11):e26747. PMID: 22069468

19. Muthenna P, Akileshwari C, Reddy GB. Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine. Biochem J. 2012 Feb 15; 442(1):221-30 PMID: 22060242

20. Vasireddy V, Chavali VR, Joseph VT, Kadam R, Lin JH, Jamison JA, Kompella UB, Reddy GB, Ayyagari R. Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation. PLoS One. 2011; 6(6):e21193. PMID: 21738619

21. Srinivas P, Narahari A, Petrash JM, Swamy MJ, Reddy GB. Importance of eye lens α-crystallin heteropolymer with 3:1 αA to αB ratio: stability, aggregation, and modifications. IUBMB Life. 2010 Sep; 62(9):693-702 PMID: 20836128

22. Saraswat M, Suryanarayana P, Reddy PY, Patil MA, Balakrishna N, Reddy GB. Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. Mol Vis. 2010 Aug 10; 16:1525-37. PMID: 20806076

23. Muthenna P, Suryanarayana P, Gunda SK, Petrash JM, Reddy GB. Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance. FEBS Lett. 2009 Nov 19; 583(22):3637-42. PMID: 19850041

24. Bhagyalaxmi SG, Srinivas P, Barton KA, Kumar KR, Vidyavathi M, Petrash JM, Bhanuprakash Reddy G*, Padma T. A novel mutation (F71L) in alphaA-crystallin with defective chaperone-like function associated with age-related cataract. Biochim Biophys Acta. 2009 Oct; 1792(10):974-81. PMID: 19595763

25. Kumar PA, Reddy GB. Modulation of alpha-crystallin chaperone activity: a target to prevent or delay cataract? IUBMB Life. 2009 May; 61(5):485-95. PMID: 19391162

26. Reddy GB, Vasireddy V, Mandal MN, Tiruvalluru M, Wang XF, Jablonski MM, Nappanveettil G, Ayyagari R. A novel rat model with obesity-associated retinal degeneration. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3456-63. PMID: 19369235

27. Saraswat M, Muthenna P, Suryanarayana P, Petrash JM, Reddy GB. Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications. Asia Pac J Clin Nutr. 2008; 17(4):558-65. PMID: 19114390

28. Saraswat M, Reddy PY, Muthenna P, Reddy GB. Prevention of non-enzymic glycation of proteins by dietary agents: prospects for alleviating diabetic complications. Br J Nutr. 2009 Jun; 101(11):1714-21. PMID: 18986599

29. Surolia I, Sinha S, Sarkar DP, Reddy PY, Reddy GB, Surolia A. Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallin. PLoS One. 2008 Aug 13; 3(8):e2927. PMID: 18698348

30. Srinivas PN, Reddy PY, Reddy GB. Significance of alpha-crystallin heteropolymer with a 3:1 alphaA/alphaB ratio: chaperone-like activity, structure and hydrophobicity. Biochem J. 2008 Sep 15; 414(3):453-60. PMID: 18479247

31. Reddy GB, Satyanarayana A, Balakrishna N, Ayyagari R, Padma M, Viswanath K, Petrash JM. Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. Mol Vis. 2008 Mar 24; 14:593-601.PMID: 18385795

32. Kumar PA, Kumar MS, Reddy GB. Effect of glycation on alpha-crystallin structure and chaperone-like function. Biochem J. 2007 Dec 1; 408(2):251-8. PMID: 17696877

33. Suryanarayana P, Saraswat M, Petrash JM, Reddy GB. Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. Mol Vis. 2007 Jul 24; 13:1291-7. PMID: 17679931

34. Mrudula T, Suryanarayana P, Srinivas PN, Reddy GB. Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem Biophys Res Commun. 2007 Sep 21; 361(2):528-32.

35. Vasireddy V, Uchida Y, Salem N Jr, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R. Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Hum Mol Genet. 2007; 16(5):471-82. PMID: 17208947

36. Reddy GB, Kumar PA, Kumar MS. Chaperone-like activity and hydrophobicity of alpha-crystallin. IUBMB Life. 2006 Nov; 58(11):632-41. Review. PMID: 17085382

37. Surolia I, Reddy GB, Sinha S. Hierarchy and the mechanism of fibril formation in ADan peptides. J Neurochem. 2006 Oct; 99(2):537-48. PMID: 17029605

38. Kumar PA, Haseeb A, Suryanarayana P, Ehtesham NZ, Reddy GB. Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat. Arch Biochem Biophys. 2005 Dec 15; 444(2):77-83. PMID: 16309625

39. Suryanarayana P, Saraswat M, Mrudula T, Krishna TP, Krishnaswamy K, Reddy GB. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):2092-9. PMID: 15914628

40. Kumar MS, Kapoor M, Sinha S, Reddy GB. Insights into hydrophobicity and the chaperone-like function of alphaA- and alphaB-crystallins: an isothermal titration calorimetric study. J Biol Chem. 2005 Jun 10; 280(23):21726-30. Epub 2005 Apr 6.

41. Suryanarayana P, Kumar PA, Saraswat M, Petrash JM, Reddy GB. Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract. Mol Vis. 2004 Mar 12; 10:148-54. PMID: 15031705

42. Kumar MS, Reddy PY, Kumar PA, Surolia I, Reddy GB. Effect of dicarbonyl-induced browning on alpha-crystallin chaperone-like activity: physiological significance and caveats of in vitro aggregation assays. Biochem J. 2004 Apr 15; 379(Pt 2):273-82.

43. Reddy GB. Fluoride toxicity and oxidative stress. Fluoride 2004; 37: 43-44

44. Reddy GB, Khandare AL, Reddy PY, Rao GS, Balakrishna N, Srivalli I. Antioxidant defense system and lipid peroxidation in patients with skeletal fluorosis and in fluoride-intoxicated rabbits. Toxicol Sci. 2003 Apr; 72(2):363-8. PMID: 12660366

45. Reddy GB, Reddy PY, Vijayalakshmi A, Kumar MS, Suryanarayana P, Sesikeran B. Effect of long-term dietary manipulation on the aggregation of rat lens crystallins: role of alpha-crystallin chaperone function. Mol Vis. 2002 Aug 21; 8:298-305. PMID: 12193883

46. Reddy GB, Narayanan S, Reddy PY, Surolia I. Suppression of DTT-induced aggregation of abrin by alphaA- and alphaB-crystallins: a model aggregation assay for alpha-crystallin chaperone activity in vitro. FEBS Lett. 2002 Jul 3; 522(1-3):59-64. PMID: 12095619

47. Reddy GB, Reddy PY, Suryanarayana P. AlphaA- and alphaB-crystallins protect glucose-6-phosphate dehydrogenase against UVB irradiation-induced inactivation. Biochem Biophys Res Commun. 2001 Apr 6; 282(3):712-6. PMID: 11401520

48. Reddy GB, Nayak S, Reddy PY, Bhat KS. Reduced levels of rat lens antioxidant vitamins upon in vitro UVB irradiation. J Nutr Biochem. 2001 Feb; 12(2):121-124. PMID: 11182556

49. Reddy GB, Das KP, Petrash JM, Surewicz WK. Temperature-dependent chaperone activity and structural properties of human alphaA- and alphaB-crystallins. J Biol Chem. 2000 Feb 18; 275(7):4565-70. PMID: 10671481

50. Reddy GB, Bhat KS. Protection against UVB inactivation (in vitro) of rat lens enzymes by natural antioxidants. Mol Cell Biochem. 1999 Apr; 194(1-2):41-5.PMID: 10391122

51. Reddy GB, Bharadwaj S, Surolia A. Thermal stability and mode of oligomerization of the tetrameric peanut agglutinin: a differential scanning calorimetry study. Biochemistry. 1999 Apr 6; 38(14):4464-70. PMID: 10194368.

52. Reddy GB, Srinivas VR, Ahmad N, Surolia A. Molten globule-like state of peanut lectin monomer retains its carbohydrate specificity. Implications in protein folding and legume lectin oligomerization. J Biol Chem. 1999 Feb 19; 274(8):4500-3. PMID: 9988681

53. Reddy GB, Bhat KS. Synergistic effect of UVB radiation and age on HMPS enzymes in rat lens homogenate. J Photochem Photobiol B. 1998 Apr; 43(1):56-60. PMID: 9639915

54. Reddy GB, Bhat KS. UVB irradiation alters the activities and kinetic properties of the enzymes of energy metabolism in rat lens during aging. J Photochem Photobiol B. 1998 Jan; 42(1):40-6. PMID: 9491595

Book Chapters:

1. GB Reddy and N Saravanan. Nutrition and eye diseases in Textbook of Human Nutrition (eds: M.S. Bamji, K. Krishnaswamy & G. N. V. Brahmam) 3rd Edn, pp 418-430, 2009, Oxford & IBH, New Delhi.

2. GB Reddy and P Suryanarayana. Diabetes and diabetic complications and Phyllanthus sp in Phyllanthus species: Scientific Evaluation and Medicinal Applications (eds: K. B. Hari Kumar & Ramadas Kuttan), pp 235-253, 2011, Taylor & Francis Group.

List of Patents:

1. ALR2 inhibitors and their synthesis from a natural source (JM Rao1, GB Reddy2, VRS Rao1 and P. Muthenna2; 1IICT & 2NIN); Patent # WO/2011117706; US 20120245357; EP 2550063 A1; Priority Data (0682/DEL/2010).

2. Antiglycating potential of procyanidin-B2 isolated from cinnamon bark: Prospects for prevention or treatment of diabetic complications (cataract, retinopathy & nephropathy) (GB Reddy, P. Muthenna, C. Akileshwari and G. Raghu). Patent filed by ICMR. (Application Number: 1452/DEL/2012)

Popular Articles:

1. Reddy GB. Nutrition and cataract. In Touch 2014; 16 (Issue 1-April-June): 2-7

2. Reddy GB. Molecular-target based nutraceuticals: Prospects for alleviating diabetic complications. Nutrition News, 2009; 30 (Issue 1)

3. Reddy GB. Diabetic complications and dietary factors. In Touch 2008; 9:4

4. Reddy GB, Suryanarayana P. Turmeric and curcumin delay cataract in rats. Nutrition News. 2005; 26 (Issue1& 2)

5. Reddy GB, Reddy PY, Suryanarayana P. Cataract: Role of nutritional chaperones. Nutrition News, 2001; 22 (Issue 2)

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