She has obtained her Masters degree in Biochemistry from the University of Hyderabad and has a Ph.D in Biochemistry from Osmania University, Hyderabad. Dr. Ismail joined the NIN in 2008 and the focus of her research is on non-classical functions of vitamin D. Vitamin D is now known to play an important role in many tissues/organs not involved in calcium homeostasis. Newer functions of this vitamin are being unraveled each year. In recent years, vitamin D deficiency has been reported to be rampant worldwide. Currently, her group is trying to understand the biochemical and molecular mechanism(s) that play a role during vitamin D deficiency in muscle and adipose tissue function. Her studies revealed that vitamin D deficiency induced muscle wasting occurs through the ubiquitin proteasome pathway. Dr. Ismail’s research indicates that both vitamin D and calcium are critical in the maintenance of normal muscle and adipose function.
Another area of her interest is the role of nutraceuticals as anticancer agents. Dietary ingredients contain phytochemicals or natural agents a.k.a ‘nutraceuticals’, which act thru multiple molecular targets and help in the prevention or treatment of cancer. Currently, work is in progress to decipher the potential anticancer role of few dietary ingredients in breast and prostate cancer models.
Dr. Ismail received post-doctoral training in the field of vitamin D at the MD Anderson Cancer Center, TX, and in the area of steroid receptors at the University of Miami, FL, USA; and is a recipient of the Young Investigator Award at the ASBMR, USA. She was awarded the Ramanujan Fellowship and Young Scientist Project from the Department of Science & Technology, India. She also received International Travel Grant from DST & ICMR. The research work in her lab is funded by DBT, DST and intramural grants from ICMR. She is a Life member of both the Nutrition Society of India (NSI) and Society of Biological Chemists India (SBC-I). She is a research supervisor in Biochemistry at Osmania University, Hyderabad, India.
1. Mehrajuddin Bhat, Bindu Noolu, Syed SYH Qadri and Ayesha Ismail. Vitamin D deficiency decreases adiposity and causes altered expression of uncoupling proteins and steroid receptor coactivator3. J Ster Biochem Mol Biol, 144, 304-312, 2014.
2. Mehrajuddin Bhat, Ramesh Kalam, Syed SYH Qadri, Seshacharyulu M and Ayesha Ismail. Vitamin D deficiency induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats. Endocrinology; 154(11), 4018-4028, 2013.
3. Bindu Noolu, Rajanna Ajumeera, Anitha Chauhan, Balakrishna Nagalla, Raghunath Manchala and Ayesha Ismail. Murraya koenegii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells. BMC Complementary & Alternative Medicine, 2013: doi: 10.1186/1472-6882-13-7.
4. Ayesha Ismail, Bindu Noolu, Shulagna Sharma, Chandana Madakasira, Mehrajuddin Bhat and Raghunath Manchala. Proteasome Inhibitory potential of commonly consumed dietary ingredients. Int J Food Nutr Sci, 1(2); 27-31, 2012.
5. IJN Padmavathi, K Rajender Rao, Laishetty Venu, Manisha Ganeshan, K Anand Kumar, Ch Narasimha Rao, Nemani Harishankar, Ayesha Ismail and Manchala Raghunath. Chronic maternal dietary chromium restriction modulates visceral adiposity: probable underlying mechanisms. Diabetes, 59, 98-104, 2010.
6. Inagadapa J.N. Padmavathi, Kalashikam Rajender Rao, Lagishetty Venu, Ayesha Ismail and Manchala Raghunath. Maternal dietary chromium restriction alters muscle development and function in the offspring. Exptl Biol and Med, 235, 349-355, 2010.
7. Ayesha Ismail and Zafar Nawaz. Nuclear hormone receptor degradation and gene transcription: An update. Review. IUBMB Life, 57(7), 483-490, 2005.
8. Obaid Y. Khan, Guilian Fu, Ayesha Ismail, Sathish Srinivasan, Xuni Cao, Yaping Tu, Shan Lu and Zafar Nawaz. Multifunction steroid receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate gland. Mol Endocrinol, 20(3), 544-559, 2006.
9. Sarath C. Dhananjayan, Ayesha Ismail and Zafar Nawaz. Ubiquitin and control of transcription. Review. Essays Biochem 41: 69-81, 2005.
10. Sarath C. Dhananjayan, Sivapriya Ramamoorthy, Obaid Y. Khan, Ayesha Ismail, Jun Sun, Joyce Slingerland, Bert W’O Malley and Zafar Nawaz. WW-domain binding protein-2 (WBP-2), an E6AP interacting protein, acts as a coactivator for estrogen and progesterone receptors. Mol Endocrinol, 20(10): 2343-2354, 2006.
11. Seema Verma*, Ayesha Ismail*, Xiuhua Gao, Guilian Fu, Xiaotao Li, Bert W.O’Malley, Zafar Nawaz. Ubiquitin-Conjugating Enzyme, UBCH7 acts as a coactivator for steroid hormone receptors. Mol Cell Biol, 24 (19): 8716-8726, 2004. *Equal Contribution.
12. Ayesha Ismail, Cuong V Nguyen, Ago Ahene, James C Fleet, Milan R Uskokovic and Sara Peleg. Effect of Cellular Environment on the Selective Activation of the Vitamin D Receptor by 1, 25-dihydroxyvitamin D3 and its Analog Ro-26-9228. Mol Endocrinol, 18(4): 874-887, 2004.
13. Peleg S, Ismail A, Uskokovic MR and Avnur Z. Evidence for tissue- and cell-type selective activation of the vitamin D receptor by Ro-26-9228, a noncalcemic analog of vitamin D3. Review. J Cell Biochem, 88(2), p.267-273, 2003.
14. Ayesha I, Bala TSS, Reddy CVK and Raghuramulu, N. Vitamin D deficiency reduces insulin secretion and turnover in rats. Diabetes Nutrition Metabolism/ Clinical and Experimental, 14(2), p.78-84, 2001.
15. Ayesha I and Raghuramulu N. Oral glucose tolerance is unaltered in vitamin D- deficient rat. J Nutr Sci Vitaminol, 46(3), p.115-118, 2000.
16. Ayesha I and Raghuramulu N. Impaired glucose tolerance in vitamin D deficiency can be corrected by calcium. J Nutr Biochem, 11, p.170-175, 2000.
17. Ayesha I, Raghunath M, Sesikeran B and Raghuramulu N. Effect of oral administration of vitamin D on glucose tolerance and insulin secretion in type 2 diabetes mellitus. Diabetes Nutrition Metabolism/Clinical and Experimental 11, 261-265, 1998.