National Institute of Nutrition
Jamai-Osmania PO
Hyderabad-500 007, India.
Ph No: #+914027197200
Email: ,
FAX: 04027019074

Name: Dr. Ayesha Ismail
Designation: Scientist ‘E’
Division: Endocrinology & Metabolism
Phone: +91-40-27197392
E-mail: ;

Brief Profile:

Dr. Ismail has a Master’s degree in Biochemistry from the University of Hyderabad and Ph.D in Biochemistry from Osmania University, Hyderabad. Before joining NIN in 2008, she received post-doctoral training at the MD Anderson Cancer Center, TX, and at the University of Miami, FL, USA.
She is a recipient of the Young Investigator Award at the ASBMR, USA. She was awarded the Ramanujan Fellowship and Young Scientist Grant from the Department of Science & Technology, India. The research work in her lab is funded by DBT, DST and ICMR. She is a Research Supervisor in the disciplines of Biochemistry and Nutrition at the Osmania University, Hyderabad, India.
Her research deals with the Non-Classical functions of Vitamin D.  Vitamin D is now known to play an important role in many tissues/organs not involved in calcium homeostasis. Newer functions of this vitamin are being unraveled each year. In recent years, vitamin D deficiency has been reported to be rampant across the world including India. Currently, her group is trying to understand the biochemical and molecular mechanism(s) that play a role during vitamin D deficiency in muscle, heart, adipose and eye function.

Another area of her interest is the role of nutraceuticals as anticancer agents. Dietary ingredients contain phytochemicals or natural agents a.k.a ‘nutraceuticals’, which act through multiple molecular targets and help in the prevention or treatment of cancer. Currently, work is in progress to decipher the potential anticancer role of few dietary ingredients using in vitro and in vivo models for breast and prostate cancer.


Total publications : 30
List of Publications in the last 10 years

  1. Ayesha I, Bindu N, Ramesh G, Shyam P, Ajumeera R, Suresh K. Cytotoxicity and proteasome inhibition by alkaloid extract from Murrayakoenigii leaves in breast cancer cells - molecular docking studies. J Med Food. 2016; 19(12): 1155-1165. PMID:27982755
  2. K. Ashok Reddy, P. Uday Kumar, M. Srinivasulu, B. Triveni, K. Sharada, Ayesha Ismail and G. Bhanuprakash Reddy. Overexpression and enhanced specific activity of aldoketoreductases (AKR1B1 & AKR1B10) in human breast cancers. The Breast. 2017; 31: 137-14. PMID:27855345
  3. Noolu B, Gogulothu R, Bhat M, Qadri SS, Reddy VS, Reddy GB, Ismail A. In Vivo Inhibition of Proteasome Activity and Tumour Growth by Murrayakoenigii Leaf Extract in Breast Cancer Xenografts and by its active flavonoids in breast cancer cells. Anticancer Agents Med Chem. 2016; 16(12): 1605-1614. PMID:27198988
  4. Shafi Syed,   Suresh Kumar Chettu,   Rajesh BM,  GajendrasinhBalvantsinhRaolji,   korupolu Raghu Babu,  N. S. KameswaraRao,   SrividyaGopalakrishnan,  Ayesha Ismail and   G. Bhanuprakash Reddy  First total Synthesis of CyclodepsipeptidesClavatustide A, B and their enantiomers. Royal Society Chemistry Adv. 2016; 6: 61555-61565
  5. BinduNoolu and Ayesha Ismail. Anti-proliferative and proteasome inhibitory activity of Murrayakoenigii leaf extract in human cancer cell lines. Disc Phytomed. 2015; 2(1): 1-9. DOI: 10.15562/phytomedicine.2015.18
  6. MehrajuddinBhat and Ayesha Ismail. Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis. J SterBiochemMol Biol. 2015; 152: 171-179. PMID:26047554
  7. MehrajuddinBhat, BinduNoolu, Syed SYH Qadri and Ayesha Ismail. Vitamin D deficiency decreases adiposity and causes altered expression of uncoupling proteins and steroid receptor coactivator3. J SterBiochemMol Biol. 2014;144, 304-312. PMID:25132457
  8. MehrajuddinBhat, Ramesh Kalam, Syed SYH Qadri, Seshacharyulu M and Ayesha Ismail. Vitamin D deficiency induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats. Endocrinology. 2013; 154(11): 4018-4028. PMID:23928374
  9. BinduNoolu, RajannaAjumeera, AnithaChauhan, BalakrishnaNagalla, RaghunathManchala and Ayesha Ismail. Murrayakoenegii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells. BMC Complement &Altern Med, 2013: doi: 10.1186/1472-6882-13-7. PMID:23302496
  10. Ayesha Ismail, BinduNoolu, Shulagna Sharma, ChandanaMadakasira, MehrajuddinBhat and RaghunathManchala. Proteasome Inhibitory potential of commonly consumed dietary ingredients. Int J Food Nutr Sci. 2012; 1(2): 27-31
  11. IJN Padmavathi, K RajenderRao, LaishettyVenu, ManishaGaneshan, K Anand Kumar, ChNarasimhaRao, NemaniHarishankar, Ayesha Ismail and ManchalaRaghunath. Chronic maternal dietary chromium restriction modulates visceral adiposity: probable underlying mechanisms. Diabetes.2010; 59: 98-104. PMID:19846803
  12. Inagadapa J.N. Padmavathi, Kalashikam RajenderRao, LagishettyVenu, Ayesha Ismail and ManchalaRaghunath. Maternal dietary chromium restriction alters muscle development and function in the offspring. ExptlBiol& Med.2010; 235: 349-355. PMID:20404053
  13. Obaid Y. Khan, Guilian Fu, Ayesha Ismail, SathishSrinivasan, Xuni Cao, YapingTu, Shan Lu and Zafar Nawaz. Multifunction steroid receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate gland. MolEndocrinol.2006; 20(3): 544-559. PMID:16254014
  14. Sarath C. Dhananjayan, SivapriyaRamamoorthy, Obaid Y. Khan, Ayesha Ismail, Jun Sun, Joyce Slingerland, Bert W’O Malley and Zafar Nawaz. WW-domain binding protein-2 (WBP-2), an E6AP interacting protein, acts as a coactivator for estrogen and progesterone receptors. MolEndocrinol, 20(10): 2343-2354, 2006. PMID:16772533
  15. Ayesha Ismail and Zafar Nawaz. Nuclear hormone receptor degradation and gene transcription: An update. Review. IUBMB Life, 57(7), 483-490, 2005. PMID:16081369

Total number of books and book chapters: 3 :
List of books and book chapters in the last 10 years
  1. Raghunath M, Ismail A and Raghuramulu N. “Fat Soluble Vitamins” in the book entitled “Text Book of Human Nutrition”, Oxford Publishers, New Delhi, 4thEdn, 2016
  2. Shalini T, Sivaprasad M, Ayesha Ismail and G Bhanuprakash Reddy“Emerging problem of Vitamin D deficiency in India”, In the “Proceedings of the Indian National Science Academy, Special issue on Nutrition; December, 2016, p1384-1391; DOI: 10.16943/pinsa/2016/48874
  3. Ayesha Ismail, Heath Catoe, SarathDhananjayan and Zafar Nawaz: “Regulation of Nuclear hormone receptor function by the Ubiquitin Proteasome Pathway” in the book entitled “Nuclear Receptor Co-regulators and Human Disease”, Chapter 3, pg 163 -193; World Scientific Publishing, June’2008.

Awards and recognition: 3
  1. Young Investigator Award at ASBMR Annual meeting, USA
  2. Ramanujan Fellowship, DST, India
  3. Young Scientist Grant, DST, India

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